A deficiency in which B vitamin can result in Megaloblastic Anemia?

Megaloblastic anemia is primarily linked to a deficiency in Vitamin B12, as well as folate (Vitamin B9). This condition is characterized by the production of abnormally large and immature red blood cells (megaloblasts) in the bone marrow. Vitamin B12 is essential for DNA synthesis in red blood cells, and without adequate amounts, the cells cannot divide properly, leading to the formation of these large, ineffective cells.

Additionally, Vitamin B12 plays a crucial role in the maintenance of the nervous system and the production of myelin, which insulates nerve fibers. Its deficiency can lead not only to megaloblastic anemia but also to neurological issues. Therefore, the critical role of Vitamin B12 in red blood cell formation and overall neurological health underscores why its deficiency is directly responsible for megaloblastic anemia.

While other B vitamins are important for various bodily functions, none of them are specifically associated with the type of anemia characterized by the megaloblastic changes seen in the cells when B12 levels are low.