Which factor is considered the primary risk factor for Nonalcoholic Fatty Liver Disease (NAFLD)?

Insulin resistance is considered the primary risk factor for Nonalcoholic Fatty Liver Disease (NAFLD) because it plays a crucial role in the development of the condition. Insulin is a hormone that helps regulate glucose levels and fat storage in the body. When the body becomes resistant to insulin, it leads to elevated levels of insulin and glucose in the bloodstream. This excess glucose is converted into fat, which the liver then accumulates, resulting in fatty liver.

Furthermore, insulin resistance is often associated with metabolic syndrome, a cluster of conditions that increase the risk of heart disease, stroke, and diabetes, all of which are commonly linked with NAFLD. Addressing insulin sensitivity through dietary and lifestyle changes can significantly improve liver health and reduce the risk of developing NAFLD.

Other factors, such as alcohol consumption, high sugar intake, and genetic predisposition, can contribute to liver health issues, but they do not have the same direct and primary role in the pathology of NAFLD as insulin resistance does. This makes insulin resistance a key factor in understanding and managing this condition.